Exosomes in cosmetology

Exosomes are a subgroup of nanosized extracellular vesicles surrounded by a lipid bilayer membrane, which are secreted by most eukaryotic cells. They are a way of intercellular communication and participate in various physiological processes. The biological role of exosomes depends on their bioactive substances, including proteins, nucleic acids and lipids, which are delivered to target cells.

In recent years, aesthetic medicine has witnessed groundbreaking progress with the introduction of therapy using exosomes.

Exosomes derived from stem cells are tiny vesicles that play a crucial role in intercellular communication and tissue repair. Their regenerative properties have opened up new opportunities in the field of aesthetic medicine, directly in skin rejuvenation and treatment of alopecia.

What are exosomes?

Exosomes are vesicles that contain a variety of proteins, lipids, and genetic material such as mRNA and microRNA. Exosomes are released from many different types of cells, including stem cells, and can circulate in the blood. They are involved in many biological processes, including intercellular communication, tissue repair, and modulation of the immune system.

exosomes inside cells — Exosomes originate from the internal budding of multivesicular bodies (MVBs) containing intraluminal vesicles (ILVs) and are released via the endosomal-lysosomal pathway.

How do exosomes work?

The therapeutic value of exosomes lies in their ability to modulate the microenvironment of cells, regulate gene expression and induce cell differentiation. Exosomes deliver targeted signals to cell genes to improve or restore the function of a damaged cell. That is, exosomes control the work of cells.

Exosomes in cosmetology and aesthetic medicine

Exosomes in cosmetology are used to reduce wrinkles, improve skin texture and hydration, increase its elasticity, and reduce inflammation and damage caused by UV radiation. In addition, exosomes are used in dermatology to promote tissue regeneration in skin wounds and to treat dermatological diseases such as systemic psoriasis, atopic dermatitis, hyperpigmentation, vitiligo and alopecia.

Unlike traditional treatment methods, exosome therapy uses the body's natural healing processes, which makes it a safe and effective option for correcting various aesthetic problems.

Exosomes for the face

Exosomes for the face are derived from mesenchymal stem cells (MSCs). They have been studied as a potential therapeutic option for improving skin texture.

The system of action of exosomes obtained from MSCs includes several mechanisms, in particular:

Skin regeneration and rejuvenation: Exosomes derived from MSCs contain growth factors and other molecules that stimulate the synthesis of own collagen, resulting in improved skin texture and tone, increased firmness and elasticity, and reduced appearance of fine lines and wrinkles.
Tissue remodeling: Exosomes also play an important role in the remodeling of the extracellular matrix of the skin, supporting the deep structures of the skin and its functions, which directly affects the strengthening of elasticity, elasticity and maintenance of a clear facial oval.
Anti-inflammatory effect: Exosomes are derived from MSCs and contain anti-inflammatory molecules such as cytokines and microRNAs that help reduce chronic inflammation that contributes to age-related skin conditions such as acne, rosacea, hyperpigmentation and hypersensitive skin.
Epidermal differentiation: Exosomes contain molecules that promote epidermal differentiation, which in turn improves barrier functions and hydration of the skin.
Antioxidant effect: The antioxidant effect of exosomes protects skin cells from oxidative stress, which accelerates the rate of skin aging.
Delivery of Active Components: Exosomes can be used as carriers to deliver active ingredients (vitamins, peptides, antioxidants) directly to the skin. This helps improve their effectiveness and penetration.
Optimizing skin health: The use of exosomes in cosmetology helps to improve the general condition of the skin, ensure its hydration and nutrition, and also support the natural protective barrier.

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Exosomes for hair

Exosomes for hair are used with both therapeutic and preventive effects.

Stimulation of hair growth: Exosomes contain biologically active components such as growth factors and proteins that stimulate hair follicles to actively grow.
Reduction of inflammation and disorders of the scalp: Certain types of exosomes have anti-inflammatory properties that help reduce inflammation or disorders that are one of the causes of hair loss.
Maintenance of hair health and nutrition: Exosomes provide hair with essential nutrients, antioxidants and vitamins that support hair health and promote hair growth.
Increasing elasticity and strengthening hair: By supporting collagen and elastin in the hair follicles, exosomes improve the elasticity and strength of the hair, preventing it from breaking and falling out.
Scalp regeneration: Exosomes stimulate the regeneration of scalp cells, which promotes healthy follicles and improves conditions for hair growth.

Treatment of hair loss (alopecia)

The treatment of hair loss with exosomes has great prospects due to the ability to change the activity and metabolism of hair root cells for a long time.

Alopecia is a medical term that describes the condition of hair loss on the scalp or other areas of the body where hair normally grows. This can appear in the form of partial or complete hair loss. The causes of hair loss can be both internal and external, including heredity, hormonal changes, internal health conditions, and medications.

Results

One of the significant advantages of therapy with exosomes is the absence of a pronounced rehabilitation period and a quick result. Results begin to appear gradually as exosomes stimulate tissue repair and collagen synthesis. In the weeks following the procedure, patients can expect continued improvement, with optimal results achieved after several months.

Exosome therapy represents a revolutionary step in the world of aesthetic medicine, offering a safe, effective and natural approach to skin rejuvenation and hair restoration. While the field of regenerative medicine is rapidly developing, exosomes provide unique opportunities in the treatment of many problems, preserving the beauty and youth of the skin, hair and health in general.
If you want quick and long-term aesthetic improvements, exosome therapy at Venus Clinic is the key to unlocking your natural beauty and youth.

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Literature

Tenchov R, Sasso JM, Wang X, Liaw WS, Chen CA, Zhou QA. Exosomes ─ Nature's Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics. ACS Nano. 2022 Nov 22;16(11):17802-17846. doi: 10.1021/acsnano.2c08774. Epub 2022 Nov 10. PMID: 36354238; PMCID: PMC9706680.
Thakur, A.; Shah, D.; Rai, D.; Parra, D.C.; Pathikonda, S.; Kurilova, S.; Cili, A. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics 2023, 10, 65.